49ers 2026 Defense

San Francisco 49ers Face Major Roster and Injury Questions for the 2026 Defense

The San Francisco 49ers season is set to begin, with questions facing the defense. Nick Bosa is returning from an ACL injury and Mykel Williams will miss six games, while Sam Okuayinonnu is on the IR. The 49ers are expected to lean heavily on Osa Odighizuwa to lead the interior defensive line group, with Alfred Collins and CJ West entering year two. They also have new defensive coordinator Raheem Morris bringing in Jack Jones, Nate Hobbs, and Ephesians Prysock to compete with Green. Who will be the third linebacker? Dre Greenlaw will start next to Fred Warner, and Garrett Wallow will back up Greenlaw. If Brown performs well, he could earn a big payday, whether it be San Francisco or another team.

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