Major Analysis Links Ultra-Processed Food Consumption to Elevated Disease and Death Risks

A pooled analysis of 51 prospective studies involving nearly 8.8 million adults linked higher ultra-processed food consumption with elevated rates of cardiovascular disease, cancer, obesity, diabetes and metabolic syndrome, depression, digestive disease, and death from any cause. People reporting the highest intake generally had greater risks than those reporting the lowest, and the analysis found risk increases as consumption rose. The findings show associations, not proof that ultra-processed foods directly cause these conditions; researchers also could not identify which foods or ingredients were responsible, and the studies had limitations including self-reported diets. Experts recommend making whole or minimally processed foods the basis of meals and reducing intake of highly processed options.
The analysis estimated that each additional 100 grams of ultra-processed food consumed daily was associated with a 14% higher cardiovascular risk, a 24% higher diabetes risk and an 18% higher risk of death from any cause.
To compare studies using different dietary measures, researchers standardized ultra-processed food intake to 50-gram servings. The studies followed participants for between two and 32 years and drew on food-frequency questionnaires, 24-hour recalls or dietary histories.
The NOVA classification includes a wide range of industrially transformed foods, from sugary drinks, packaged snacks and processed meats to some breads, yogurts and chocolates with differing nutritional profiles.
Researchers have not resolved whether the observed associations stem mainly from nutritional characteristics such as sugar and salt, or from food processing itself.
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