No. 20 Oregon visits No. 12 USC in a pivotal Big Ten matchup.

Oregon coach Dan Lanning has gone 50-9 since taking over the program in 2022 and has led the Ducks to consecutive College Football Playoff appearances.
USC’s early schedule consisted of three home games against San José State, Fresno State and Louisiana-Lafayette before the Rutgers road game, making Oregon the Trojans’ first major test of the season.
USC receiver Trent Mosley, who had 255 receiving yards and four touchdowns in his first three appearances, was sidelined against Rutgers with a knee injury and could be unavailable against Oregon.
Jayden Maiava has completed 75.7% of his passes and thrown only one interception through USC’s first four games, adding efficiency to his conference-leading totals in passing yards and touchdowns.
The matchup was expected to be closely contested by oddsmakers: FanDuel listed Oregon as a 2.5-point favorite, with a -140 moneyline for the Ducks and an over-under of 62.5 points.
No. 20 Oregon visits No. 12 USC on Saturday in a sold-out Los Angeles Memorial Coliseum for a pivotal Big Ten matchup with College Football Playoff implications. The Trojans enter 4-0 behind quarterback Jayden Maiava, who leads the conference with 1,173 passing yards and 12 touchdowns. The Ducks arrive 2-1 after an upset loss at Oklahoma State, seeking to prove they've fully recovered under coach Dan Lanning, who remains unbeaten on the road in Big Ten play.
USC's high-octane offense has faced only weak nonconference opponents. The Trojans beat San José State, Fresno State, and Louisiana-Lafayette at home before a narrow 28-27 road win over winless Rutgers—a game that exposed defensive vulnerabilities. Oregon won the past four meetings between these former Pac-12 rivals, including the last two in Los Angeles. FanDuel lists the Ducks as 2.5-point favorites with an over-under of 62.5 points.
USC's 4-0 record comes against cupcake opponents. The Trojans dominated three FBS teams at home: San José State, Fresno State, and Louisiana-Lafayette all played in the Coliseum. Daily Breeze reports that USC struggled to start games with authority in recent weeks. Against Rutgers, the Trojans allowed 460 yards and 35 points in a 28-27 nail-biter that revealed serious cracks in the secondary and run defense.
Oregon's defense can punish slow starts. Lanning's squad has won four straight against USC and took the last two games in Los Angeles. With experienced talent on both sides of the ball, the Ducks should test whether the Trojans' offense can sustain drives when the pressure ramps up.
Jayden Maiava looks sharp on paper: 75.7% completion rate with just one interception through four games. His 1,173 passing yards and 12 touchdowns lead the Big Ten by a comfortable margin. But these stats came against soft competition. Oregon linebacker and secondary will provide his first real test of the season.
Receiver Trent Mosley, who posted 255 yards and four touchdowns in USC's first three games, suffered a knee injury against Rutgers and may be unavailable Saturday. Losing a receiver of that caliber narrows Maiava's options and forces the offense to lean harder on freshman talent.
Dan Lanning is 50-9 since taking over Oregon in 2022 and has led the Ducks to back-to-back College Football Playoff appearances. Most impressively, he has not lost a Big Ten road game—a streak that includes tough environments like the Coliseum. The sold-out crowd will test Oregon's poise, but Lanning's experience suggests the Ducks can execute in hostile territory.
Dante Moore leads Oregon's offense with the kind of mobility and arm talent that can stress USC's secondary. The matchup hinges on whether USC's firepower can overcome early-game jitters, and whether Oregon can capitalize on any mistakes the Trojans make on the Coliseum grass.
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