NFL Week 1 Preview
NFL Week 1 features crucial injury reports, betting odds, and high-profile matchups ahead of Sunday.
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Key Points
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Packers running back Josh Jacobs appeared in court in Green Bay and pleaded no contest to misdemeanor charges of battery and criminal damage to property.
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Vikings head coach Kevin O’Connell said safety Harrison Smith is still “getting his cleats underneath him,” leaving his availability for the opener against Green Bay uncertain.
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The 49ers-Rams game is scheduled for an 8:35 p.m. ET kickoff at Melbourne Cricket Ground; Los Angeles is listed at -205 on the money line and San Francisco at +170.
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Both teams finished 12-5 in 2025 and tied for second in the NFC West. The Rams are seeking their third Super Bowl appearance in nine seasons, while the 49ers are pursuing their third in eight seasons.
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The Rams went 12-5 against the spread last season, the best mark in the league, while San Francisco finished 10-6-1 against the spread.
NFL Week 1 kicks off with five key matchups, but injury concerns are already shaping Sunday's games. The San Francisco 49ers and Los Angeles Rams—both 12-5 teams tied for second in the NFC West—clash in Melbourne at 8:35 p.m. ET, with the Rams favored by 3.5 points Ledger-Enquirer. Multiple divisions face lineup uncertainties as teams prepare for opening day.
Chicago visits Carolina with Chicago's Rome Odunze expected to practice Friday, while Carolina's Jonathan Brooks has practiced three consecutive days. Carolina's Jonathan Jones is not expected to play Bradenton. Green Bay's Xavier McKinney's status remains uncertain ahead of Minnesota, where Vikings safety Harrison Smith is still 'getting his cleats underneath him' Tri-City Herald.
49ers-Rams Melbourne Showdown Sets High Stakes
The 49ers and Rams meet in Australia for a heavyweight matchup. Los Angeles is favored at -205 on the money line, with San Francisco at +170 Macon. The projected total is 48.5 points. Both teams tied for second in the NFC West after finishing 12-5. The Rams are chasing their third Super Bowl appearance in nine seasons, while the 49ers pursue their third in eight seasons.
Injury Questions Cloud Green Bay-Minnesota Opener
The Packers face uncertainty with safety Xavier McKinney's status before facing Minnesota. Vikings head coach Kevin O'Connell expressed caution about safety Harrison Smith, saying he is still 'getting his cleats underneath him' for the opener The Olympian. Green Bay tight end Tucker Kraft remains healthy and is not on the injury report. Meanwhile, Minnesota's J.J. McCarthy will serve as the third-string quarterback.
Arizona-Los Angeles Bruised With Early-Season Woes
Arizona at Los Angeles faces multiple injury setbacks. Los Angeles defensive lineman Dadrion Taylor-Demerson missed practice due to rib issues. Isaiah Williams remained limited in practice, while Elijah Love was warming up ahead of sessions Ledger-Enquirer. The Chargers are managing several early-season injuries as they open at SoFi Stadium in Inglewood.
Packers' Josh Jacobs Appears in Court on Charges
Packers running back Josh Jacobs faced legal trouble ahead of Week 1. Jacobs appeared in court in Green Bay and pleaded no contest to misdemeanor charges of battery and criminal damage to property Bradenton. The plea marks another distraction for Green Bay as it prepares for its Minnesota matchup.
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