Global Analysis Estimates That Infections Were Linked to 2.3 Million New Cancer Cases

H. pylori was linked mainly to stomach cancer, while HPV was associated with nearly all cervical cancers as well as some cancers of the anus, penis and throat. Hepatitis B and C were mainly linked to liver cancer, and Epstein-Barr virus primarily to nasopharyngeal cancer.
The analysis estimated that H. pylori and HPV were each associated with about 750,000 cancer cases.
The researchers cautioned that an infection being attributed to cancer cases at the population level does not mean it directly caused every individual cancer included in the analysis.
Study co-author Dr. Harriet Rumgay said the findings “underscore the major role that infection control can play in reducing the global cancer burden,” while warning that infection-related cancers remain a major challenge despite progress in vaccination and screening.
A global analysis estimates that infections caused 2.3 million new cancer cases in 2024, accounting for roughly 1 in 8 cancers worldwide Live Science. The study, published in The Lancet Oncology, identified 12 infectious agents linked to cancer, with Helicobacter pylori and HPV each responsible for about 750,000 cases Yahoo News. Researchers say many of these cancers could be prevented through vaccination, screening, and infection treatment.
About three-quarters of infection-linked cancers occurred in low- and middle-income countries, with Eastern Asia bearing the largest regional burden Knowridge. Study co-author Dr. Harriet Rumgay said the findings "underscore the major role that infection control can play in reducing the global cancer burden." Experts warn that despite progress in vaccines and screening, infection-related cancers remain a significant challenge.
Helicobacter pylori and HPV each accounted for roughly 750,000 cancer cases in 2024 IJR. H. pylori bacteria primarily triggers stomach cancer through chronic inflammation. HPV, a sexually transmitted virus, causes nearly all cervical cancers plus some cancers of the anus, penis, and throat. Together, these two pathogens represent about half of all infection-linked cancers globally.
Hepatitis B and C viruses primarily cause liver cancer and remain major cancer culprits worldwide Yahoo News. Epstein-Barr virus, which causes mononucleosis, is mainly linked to nasopharyngeal cancer. These four infections — H. pylori, HPV, hepatitis B, and hepatitis C — account for the bulk of infection-associated cancers. The study also examined eight other infectious agents, though they contributed smaller percentages to the global total.
About 75 percent of the 2.3 million infection-linked cancer cases occur in low- and middle-income countries Knowridge. Eastern Asia carries the largest regional share, driven by high rates of H. pylori and hepatitis B infections. Wealthy nations have better access to vaccines and screening programs that prevent many of these cancers. This disparity highlights how infection control remains a major global health challenge in poorer regions.
Researchers emphasize that vaccination, screening, and infection treatment could prevent a large portion of these cancers Live Science. HPV vaccines already protect against cervical cancer when given before infection. Hepatitis B vaccines have dramatically reduced cases in countries with strong immunization programs. However, the analysis likely underestimates true numbers since it only included infections already proven to cause cancer and relied on available population data.
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