MLB slate features five Sept. 22 games

Arizona has won 37 of the 66 games in which it was favored this season and is 4-1 when listed at -188 or longer, while Colorado is 15-41 as an underdog at +158 or longer.
Seattle is 21-16 when favored by at least -154 this season, while Houston has gone 40-41 as a moneyline underdog; the Mariners’ 56-98 record against the spread is notably poor despite their projected victory.
The Athletics have gone 14-18 in games as favorites this season and are 73-82 against the spread, while the Angels are 44-82 as moneyline underdogs and have gone over the total in 64 games.
Chicago is 59-44 when favored this season, but has won only two of four games when priced at -210 or longer; Miami is 35-53 as an underdog and 2-3 when listed at +176 or longer.
The Dodgers-Padres matchup includes several recent roster and performance notes: Fernando Tatis Jr. homered Sunday, Andy Pages was activated from the 10-day injured list, and Roki Sasaki returned from the 15-day injured list. The source lists San Diego starter as Robbie Ray (3-2, 5.22 ERA), not Dylan Cease.
Five MLB games on September 22 offer varied betting opportunities across the league. FanDuel projects Arizona to beat Colorado 54.8% of the time, Seattle to top Houston 58.2% of the time, and Chicago to defeat Miami 63.7% of the time. The Athletics face the Angels in a pick'em matchup, while the Dodgers host the Padres in a separate contest.
Arizona enters as a -188 favorite with a 54.8% projected win probability. Mike Soroka starts for the Diamondbacks while Kyle Freeland takes the mound for Colorado. FanDuel sets the game total at 10.5 runs. Arizona has won 37 of 66 favored games this season and is 4-1 when listed at -188 or longer odds.
Colorado enters as a significant underdog at +158 odds. The Rockies carry a poor record as underdogs, winning just 15 of 41 games when listed at +158 or longer this season. The matchup presents a stark contrast in recent form and betting success between the two teams.
Seattle has a 58.2% projected win probability as a -154 home favorite. Logan Gilbert starts for the Mariners while Cristian Javier takes the mound for Houston. FanDuel sets the total at 7.5 runs. Seattle is 21-16 when favored by at least -154 this season, showing solid success in similar spots.
Houston enters as an underdog with a 40-41 record in moneyline underdog situations this season. The Mariners' record against the spread is notably poor at 56-98 despite their strong projected winning percentage. Seattle's recent offensive performance and home-field advantage drive the betting projection.
Chicago projects as the slate's strongest favorite with a 63.7% win probability at -210 odds. Kevin Gausman starts for the Cubs against Miami's Janson Junk. FanDuel sets the total at 6.5 runs. Chicago is 59-44 when favored this season but has won only two of four games when priced at -210 or longer.
Miami carries a 35-53 record as an underdog this season and is 2-3 when listed at +176 or longer. The Marlins face a sharp projection disadvantage in this matchup. Chicago's recent form and pitching advantage explain the wide betting gap between the two teams.
Oakland receives a 57.2% projected win probability in an even-money matchup against Los Angeles. Brady Basso starts for the Athletics while Yusei Kikuchi takes the mound for the Angels. FanDuel sets the total at 9.5 runs. Oakland is 14-18 in games as favorites this season and 73-82 against the spread.
Los Angeles carries a 44-82 record as a moneyline underdog and has gone over the total in 64 games this season. The high game total reflects both teams' offensive tendencies. The close projected probability suggests bettors should expect a competitive contest without a clear favorite.
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